| abstract |
The invention relates to an aminopyrimidine compound represented by formula (I), a polymorph, a pharmaceutically acceptable salt, a prodrug, a stereoisomer, an isotope variant, a hydrate or a solvate thereof, a pharmaceutical composition comprising it, and an associated use. The aminopyrimidine compound and the composition comprising it have excellent inhibition against protein kinases, and at the same time have better pharmacokinetic parameter characteristics, and can improve the drug concentration of the compound in animals, and by therefore, may improve the efficacy and safety of the drug. |