| abstract |
An intermediate drug having synergistic anticancer activity and a polyethylene glycol-conjugated synergistic anticancer drug, and a preparation method and application thereof. The structural formula of the intermediate drug is (I), and the structural formula of the polyethylene glycol-coupled synergistic anticancer drug is (II), and the above-mentioned drugs can realize a combination of various anticancer drugs, avoiding being separate When taking a variety of anticancer drugs, due to the interaction between drugs and pharmacokinetics, and it is beneficial to overcome the multidrug resistance of cancer, it has synergistic effect and can be used to prepare anticancer drugs. And for the treatment of cancer. |