abstract |
The present invention provides a recombinant vaccine against Lawsonia intracellularis based on a recombinant synthetic chimeric variant of membrane proteins and invasins of said bacterium. Additionally, the invention discloses synthetic nucleotide sequences encoding said protein variants, recombinant proteins as such, a cassette for expression of said synthetic protein antigens, a transformed cell and a method for the production of said antigens, demonstrating their antigenicity and potential for protection against pathogen Lawsonia intracellularis . |