| abstract |
The invention relates to pharmaceutical compositions for the oral route comprising amantadine or a corresponding pharmaceutically acceptable salt, as well as a pharmaceutically acceptable excipient, which contain a low level of organic solvent. The invention also relates to methods of orally administering to a subject a composition comprising amantadine, or a corresponding pharmaceutically acceptable salt, which exhibits fewer gastrointestinal side effects or sleep disturbances. The invention further relates to sustained release compositions for the oral route comprising amantadine, or a pharmaceutically acceptable salt thereof, which are suitable for a single daily administration. |