http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019036299-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a5e95156255d5fe8b2923c544786e176 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0053 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| filingDate | 2018-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44acf93876120b943e24f6c44ea0597a |
| publicationDate | 2019-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2019036299-A2 |
| titleOfInvention | PROTECTION OF NORMAL TISSUES IN THE TREATMENT OF CANCER |
| abstract | The present invention provides methods of treating individuals with cancer. In some methods, the cancers may be devoid of functional guanylyl cyclase C and / or p53. In some methods, methods include protecting gastrointestinal cells against genotoxic damage by administering one or more compounds sufficient to elevate intracellular cGMP in gastrointestinal cells, and then administering chemotherapy. and / or radiotherapy to kill cancer cells. In certain methods, the method comprises administering one or more guanylyl-cyclase C agonist compounds to intestinal stem cells in the individual in an amount sufficient to activate guanylyl-cyclase C of the intestinal stem cells and elevate the intracellular cGMP in intestinal stem cells, and then administration of chemotherapy and / or radiation to kill cancer cells. |
| priorityDate | 2017-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 859.