| abstract |
Antibody molecules and antigen-binding portions thereof that specifically bind to CD47 (differentiation group 47, also referred to as integrin-associated protein [IAP]) are provided. In particular aspects of the invention, the anti-CD47 antibody molecules and antigen-binding portions thereof specifically bind to human CD47 and cynomolgus monkey CD47. The invention also relates to medical uses of the anti-CD47 antibody molecules and antigen binding portions of the invention. The anti-CD47 antibody molecules and the antigen-binding portions of the invention represent modified and optimized binding molecules by comparison with murine / humanized anti-CD47 VxP037 antibody described in WO2014 / 093678A2. |