| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b1c43a1edbed2f4cce803c2ba180f1ea
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c731b1258bdc5ec03140bf17ca27dc40 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-052
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0331 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-5443
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0278
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-078
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-54 |
| filingDate |
2018-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35566861c5b5b0244916dfbaf04172fd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7eff6ed687d7d7b310a23fbeda15b343
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85aef04475074f843ed3c75a4eb66cfd |
| publicationDate |
2019-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2019032836-A1 |
| titleOfInvention |
IMMUNODEFICIENT MOUSE EXPRESSING THE HUMAN INTERLEUKINE 15 |
| abstract |
The present invention relates to an immunodeficient mouse that is useful as a model for the functions and regulation of human natural killer (NK) cells and other interleukin-15 (IL-15) -dependent cell populations and processes in studies of human immunity, cancer, infectious diseases and other areas. According to certain specific aspects, the invention relates to an immunodeficient mouse that is genetically engineered to express human interleukin, wherein the mouse does not or does not produce functional mouse natural killer cells, and the mouse is modified to include natural human killer cells. The invention also provides methods for identifying an antitumor activity of a test substance using a mouse of the present invention as well as methods for producing said mouse. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111485001-A |
| priorityDate |
2017-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |