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publicationDate 2019-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2019028686-A1
titleOfInvention GENITAL INACTIVATION METHOD
abstract The present invention provides a donor construct, a gene inactivation method, and an associated system and kit. The donor construct is a linear donor DNA or may be cleaved in a cell to produce the linear donor DNA. The gene inactivation method utilizes a marker gene contained in the donor construct to enrich cells in which a gene is inactivated to enhance the gene inactivation generation efficiency using a sequence-specific nuclease.
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