| abstract |
In accordance with the present invention, high concentration, low viscosity nucleic acid compositions, which can be administered by multiple parenteral routes, may allow less frequent dosing than currently available nucleic acid products. In particular, low viscosity defibrotide formulations for subcutaneous, intramuscular and intraperitoneal administration are more convenient for the patient and / or may be administered outside the hospital setting. The formulations of the invention can be used for the treatment of numerous conditions including, for example, the treatment of peripheral arterial diseases, treatment of acute renal failure, treatment of acute myocardial ischemia, and treatment and prevention. sinusoidal obstruction syndrome, or veno-occlusive disease. |