| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_47338c859c5e688d3742bbf9e3801988 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-82 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 |
| filingDate |
2018-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec4dd9d327941373b4efb248b911d501
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66db4662169ad0eb5023036d3ee2f508
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6acfe21e15e741d56b78b5246d022fe7 |
| publicationDate |
2019-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2019023263-A1 |
| titleOfInvention |
METHODS AND COMPOSITIONS FOR TREATING TUMORS COMPRISING A BCR-ABL1 FUSION GENE |
| abstract |
Embodiments of the invention provide methods and compositions for the treatment and mitigation of tumors comprising a BCR-ABL1 fusion gene. In some embodiments, a tumor comprising a BCR-ABL1 fusion gene, such as chronic myeloid leukemia (CML) tumor, can be treated by reducing NOX2 activity in a subject's cell. In some embodiments, the NOX2 activity can be reduced by the administration of an NOX2 inhibitor, such as histamine dihydrochloride (HDC). |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11365441-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020206184-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3947674-A4 |
| priorityDate |
2017-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |