| abstract |
The present technology relates to stimulatory molecules of the immunological system for use in the treatment of drug dependence and misuse, as well as their methods of synthesis. These molecules comprise a chemical structure of the calixarene type, preferably calix [4 arene and / or calix [8] arene, coupled to a cocaine analogue hapten, preferably GNE and / or CNG. The invention also relates to a vaccine against drugs, especially anti-cocaine, using these molecules. This anti-drug vaccine can also be used to prevent fetal drug exposure in pregnant women who are drug users who do not want or can not stop using it during pregnancy. |