| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_870eb0bfda8e9252517b2b7ae44506e0 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-7233 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-22 |
| filingDate |
2018-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d24a5efd4bf93d788018e8b6f809a552
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f436671af69641cfd1a20e54c3e3bdb5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4765edbd7dcf9f51f7b3df4ce4db730
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74be70e6d310b519536202c205b4a99a |
| publicationDate |
2019-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2019020821-A1 |
| titleOfInvention |
PROCESS FOR THE PREPARATION OF LAUROXIL ARIPIPRAZOLE |
| abstract |
The invention relates to a process for the preparation of aripiprazole lauroxil which comprises the reaction of 1- (hydroxymethyl) aripiprazole with lauric acid in the presence of a suitable solvent and a carboxyl activating agent in the presence of a appropriate solvent and, optionally, in the presence of a suitable base. The - (Hydroxymethyl) aripiprazole may be prepared by reacting aripiprazol or a hydrate thereof with paraformaldehyde in the presence of a suitable organic solvent and a suitable base, the reaction being carried out without the addition of water as a solvent to the reaction mixture. In addition, (7- (4- (4- (2,3-dichlorophenyl) piperazin-1-yl) butoxy) -3,4-dihydro-2-oxoquinolin-1 (2H) -yl) methyl formate is provided under form of a reference standard. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110749677-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021009087-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110849995-A |
| priorityDate |
2017-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |