| abstract |
The invention provides chimeric antigen receptors that target mesothelin and uses thereof. The chimeric antigen receptor provided by the invention comprises a membrane protein signal peptide, an anti-mesothelin proximal membrane single-chain antibody, a hinge region of 50 amino acid residues or more, a transmembrane region, and a costimulatory stimulation from the N-terminus to the C-terminus. Signaling molecule intracellular domain and immunoreceptor tyrosine activation motif. The present invention also provides a T cell expressing the chimeric antigen receptor, which can specifically kill a tumor cell strain with high expression of mesothelin, and has little or no killing effect on a tumor cell line which is not expressed, and has a very high Good specificity. |