| abstract |
The invention relates to a chiral 3-quinuclidone compound, a method of preparation and use. In particular, the present invention relates to a compound represented by the general formula Ia or IB or a pharmaceutically acceptable salt, isomer or a mixture thereof, a solvate, a polymorph, a stable isotopic derivative, or a prodrug thereof. as well as a method of preparation and an application thereof. The compound has a good inhibitory activity of cell proliferation and pharmacokinetic properties and can be used in the treatment of cancer, autoimmune diseases, etc. (IA) (IB) |