| abstract |
The invention relates to a method for preventing, delaying or treating cancer in a subject, comprising administering, to a subject in need thereof, a PARP inhibitor, in particular (R) - 2-fluoro-10a-methyl-7,8,9,10,10a, 11-hexahydro-5,6,7a, 11-tetraazacyclohepta [def] cyclopenta [a] fluoren-4 (5H) -one, a corresponding sesquihydrate or a corresponding pharmaceutically acceptable salt, in combination with temozolomide and / or radiotherapy. The invention also relates to a pharmaceutical combination comprising a PARP inhibitor, in particular (R) -2-fluoro-10a-methyl-7,8,9,10,10a, 11-hexahydro-5,6,7a, 11 tetraazacyclohepta [def] cyclopenta [a] fluoren-4 (5H) -one, a corresponding sesquihydrate or a corresponding pharmaceutically acceptable salt, in combination with temozolomide and its use. |