| abstract |
The present invention relates to compositions and methods for closing wounds. A device comprising: a) a material having a surface comprising modified fibrinogen or modified fibrin, the modified fibrinogen or modified fibrin being more resistant to fibrinolysis than, respectively, unmodified fibrinogen or non-fibrinogen; modified; and b) one or more fibrinolysis dispersible inhibitor (s) in contact with the surface comprising a plasmin inhibitor; and c) optionally, a thrombin-like agent or platelets. |