Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6e791faa77bd44b4cad94a045fe97708 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-15043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2539-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14143 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6876 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0696 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-067 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-074 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6876 |
filingDate |
2018-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b37f10990dfe46ed53bf9b39e9d5817f |
publicationDate |
2019-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2019012259-A1 |
titleOfInvention |
METHOD FOR TESTING A GENE THERAPY VECTOR |
abstract |
The invention relates to a method for determining the safety and / or efficacy of a gene therapy vector prior to performing gene therapy on an individual, comprising infecting an induced pluripotent stem cell culture. obtained from the individual with a gene therapy vector. Ideally, the cells are made to differentiate, and the infection is made at the beginning of the culture and at least once during the differentiation and / or after the differentiation. Nucleic acids are extracted from the infected cells and then analyzed to measure and / or determine adverse effects of nucleic acid integration from the vector and / or the efficiency of nucleic acid expression from the vector. . |
priorityDate |
2017-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |