| abstract |
The present invention provides imidazo[1,2-b]pyrimido[4,5-d]pyridazin-5(6H)-one compounds. In particular, the invention provides a compound of formula I, or a pharmaceutically acceptable salt or prodrug thereof: (I) wherein A, R1-R5 are as defined herein. The compound of formula I is a Wee1 kinase inhibitor. Thus, the compounds of the invention are useful in the treatment of diseases caused by abnormalities in Weel activity. |