| abstract |
The present invention provides methods, compositions, reagents, systems and kits for preparing a nitroxide-functionalized nitroxide-based (NCO-BAS) polymeric organic radical contrast agent and compositions and uses thereof. them. Various embodiments show that BASP-ORCA displays nitroxide and cross-molecule relaxivities per molecule for organic radical contrast agents, exceptional stability, high solubility in water, low toxicity in vitro and in vivo , and a long half-life of blood compartment. These materials have the potential to be adopted for tumor imaging using clinical techniques 1 MRI High field. |