abstract |
The present invention relates to inhibitors of TDO2 and IDO1 and pharmaceutical compositions thereof useful for modulating tryptophan 2,3 dioxygenase and indoleamine 2,3-dioxygenase 1 activity; treat immunosuppression; to treat disease states that are enhanced by inhibition of tryptophan degradation; to increase the effectiveness of an anticancer treatment by administering an anti-cancer agent; treat cancer-specific tumor specific immunosuppression. |