| abstract |
The invention provides compositions, systems, kits and methods for treating nervous system lesions caused by trauma or neurodegeneration or aging in a subject by administering a CSPG or SOCS3 reduction peptide. (CRP and SRP, respectively), or a nucleic acid sequence encoding CRP or SRP, the CRPs and SRPs comprising a cell membrane penetration domain, and a lysosome targeting domain and the CRP further comprising a chondroitin sulfate proteoglycan (CSPG) binding domain, and the SRP further comprising a cytokine-3 signaling binding domain suppressor (SOCS3). |