| abstract |
The present invention relates to antisense oligonucleotides for modulating the function of a T cell, and comprises antisense oligonucleotides that hybridize to IFN-gamma, granzyme, perforin 1, PD-1, PRDM1, PD-L1, CD40LG, NDFIP1, PDCD1 LG2, REL, BTLA, CD80, CD160, CD244, LAG3, TIGIT, ADORA2A and TIM-3 RNAs. In particular, the present invention relates to antisense oligonucleotides capable of inducing RNA exon skipping. Also claimed is a method of further modifying the specificity of said T-cell by providing a T-cell receptor gene. |