| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c0e4fd0623b68f3d46f6911d868fe07c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2730-10122 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-706
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-165
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165 |
| filingDate |
2018-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73f7bcc444f93edd04cbfbe335360ee1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c01a2d5950bf5bd24c14be9bfad28bf2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_933a323afbd967d507ef8da39316b3e5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4be7612d509849b8c86b83647620157
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81fef0f60050f1dcb51f040d297230dc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a22402161682efe9a61d4a70386f1ce9 |
| publicationDate |
2018-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2018237369-A2 |
| titleOfInvention |
LIPID NANOPARTICLE MEDIA ADMINISTRATION OF PLASMIDIC DNA EXPRESSING CRISPR FOR THE TREATMENT OF CHRONIC INFECTION WITH HEPATITIS B VIRUS |
| abstract |
The present invention relates to plasmid DNA expressing CRISPR and a gene delivery system targeted to hepatocytes infected with the hepatitis B virus. The invention also relates to methods for orienting the formation of a CRISPR system in these cells to ensure improved specificity of target recognition to modify, improve or treat chronic HBV infection. In addition, the CpG content of the expression plasmid DNA was minimized to reduce inflammation and maximize gene expression. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021046265-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2614223-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022198229-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020225719-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114929205-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022262050-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020181182-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3957734-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2600568-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114008200-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021123332-A1 |
| priorityDate |
2017-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |