http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018236678-A1

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publicationDate 2018-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2018236678-A1
titleOfInvention ORAL DISSOLUTION MELATONIN FORMULATION WITH ACIDIFYING AGENT THAT MAKES MELATONIN SOLUBLE IN SALIVA
abstract A composition comprises a pharmaceutical dosage form configured to integrate into saliva and maintain a pH of 4 or less within the saliva during the time when the dosage form is dissolved therein. The dosage form comprises a therapeutically effective amount of melatonin in a carrier matrix, a disintegrating agent, and a sufficient amount of acid to impart pH to the saliva. The amount of the disintegrating agent is sufficient to cause complete disintegration of the dosage form in saliva within ten minutes of contact with saliva.
priorityDate 2017-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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