| abstract |
The present invention relates to an in situ phase change gel sustained release preparation for a small molecule drug and its method of preparation. The in situ phase-change gel sustained-release preparation comprises a small molecule drug comprising a pharmaceutical active ingredient, a phospholipid, Span, and an ethanol solution. The in situ phase change gel sustained-release preparation has a high concentration of phospholipids combined with Span, and thus is capable of reducing the immediate release of the small molecule drug and extending the release time, and is appropriate to various routes of administration, such as subcutaneous injection and external administration. |