http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018229195-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_25c76b5b8293c2914fadced494084bcf |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 |
| filingDate | 2018-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e22bb45038f6111093a6fcd8b8b7079a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0888566d8c0e181d483d9cc1e7d508ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_807b341691e60fd0bb6d539e5f65886a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed862b876b24b838b7d3ed53e0c69646 |
| publicationDate | 2018-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2018229195-A1 |
| titleOfInvention | Bicyclic heteroaromatic amide compounds for use in therapy |
| abstract | The present invention relates to compounds of the formula I as described below or a tautomer or a pharmaceutically acceptable salt thereof; to a pharmaceutical composition containing such compounds; and to said compounds of the formula I or a tautomer or a pharmaceutically acceptable salt thereof for use as a medicament, especially for use in the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularization, wherein X 1 is CR 1 or N; X 2 is CR 2 or N; X 3 is CR 3 or N; X 4 is CR 4 or N; Y 1 is N, NR 5a , S, O or CR 5b ; Y2 is N, NR 5c , S, O or CR 5d ; Z is N or C; with the proviso that at most two of X 1 , X 2 , X 3 and X 4 are N; with the proviso that Y 1 is not O if Y2 is CR5d and simultaneously Z is C; with the proviso that Y 1 and Y 2 are not both simultaneously O or S; with the proviso that at least one of Y 1 , Y 2 and Z is a heteroatom or heteroatom-containing group; L 1 is a bond, optionally substituted C 1 -C 6 -alkylene or C 3 -C 8 -cycloalkylene; L 2 is a bond, optionally substituted C 1 -C 6 -alkylene, C 3 -C 8 -cycloalkylene etc.; A is 3-, 4-, 5-, 6-, 7- or 8-membered optionally substituted, saturated, partially unsaturated or maximally unsaturated carbocyclic or heterocyclic ring; or L 2 -A forms a group C 1 -C 6 -alkylene-OR 13 , C 1 -C 6 -alkylene-SR 14 or C 1 -C 6 -alkylene-NR 15 R 16 ; and R 1 , R 2 , R 3 , R 4 , R 5a , R 5b , R 5c , R 5d , R 6 , R 13 , R 14 , R 15 and R 16 are as defined in the claims and the description. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022211518-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102547762-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021066573-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20210040803-A |
| priorityDate | 2017-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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