| abstract |
The present invention provides compositions (e.g., nanoparticles) comprising a conjugated polyethyleneimine (PEI) polymer (a "conjugated lipomer"), or a pharmaceutically acceptable salt thereof, and a lipid-PEG conjugate, wherein the conjugated lipomer of Formula (I) contains one or more groups of the formula (iii). Compositions of the invention are useful for the delivery of active agents, for example, for the treatment of disease. Or a pharmaceutically acceptable salt thereof, wherein: each instance of L1 is independently selected from the formulae: provided that at least one L is selected from formula (iii); and a lipid-polyethylene glycol (PEG) conjugate of Formula (II): |