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filingDate 2018-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2018-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2018222503-A1
titleOfInvention Adeno-associated virus with variant capsid and methods of use thereof
abstract The present disclosure provides recombinant adeno-associated virus (AAV) virions with altered capsid protein, where the recombinant AAV (rAAV) virions exhibit greater infectivity of a cardiac cell compared to wild-type AAV, and where the rAAV virions comprise a heterologous nucleic acid. The present disclosure provides methods of delivering a gene product to a cardiac cell in an individual. The present disclosure provides methods of generating an induced cardiomyocyte-like cell. The present disclosure provides methods of editing the genome of a cardiac cell.
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023172491-A1
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