| abstract |
The invention relates to a method for producing a modified non-ribosomal peptide, for example a modified microcystin and / or a modified nodularin (together CA), comprising the following steps: a) growth of a modified non-ribosomal peptide producing a strain cyanobacteria in a culture medium, b) adding one or more modified substrates preferably modified amino acids to said culture, and c) inoculating the strain producing the non-ribosomal peptide in the presence of said modified substrates. The non-ribosomal peptide thus modified can be used for the therapy of various diseases. |