| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc2b03342511abc88f60c63f2acd96d0 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6923
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1866 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01R33-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-06 |
| filingDate |
2018-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46a98af677e420ac0c6d04f5da104453
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cca8da9ccf804c6689ce6dbce704acae |
| publicationDate |
2018-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2018217943-A1 |
| titleOfInvention |
Anti-warburg nanoparticles - a matrix metalloprotease activatable conjugate to inhibit glioblastoma proliferation |
| abstract |
A matrix metalloprotease (MMP) activatable conjugate is provided to inhibit glioblastoma (GBM) proliferation through glioma tumor cell and glioma stem cell differentiation. The conjugate is structurally characterized by having dichloroacetate (DCA), as a therapeutic drug, linked, via a MMP cleavable peptide, to a nanoparticle suitable for magnetic resonance imaging (MRI) such as a superparamagnetic iron oxide (SIPO) or an ultra superparamagnetic iron oxide (uSIPO). |
| priorityDate |
2017-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |