| abstract |
The invention relates to a composition comprising a viral vector, the viral vector comprising nucleic acid having a polynucleotide sequence encoding the spike protein from the middle eastern respiratory syndrome coronavirus (MERS-CoV), characterised in that said viral vector is an adenovirus based vector. Suitably said adenovirus based vector is ChAdOx 1, and said spike protein is full length spike protein. More suitably said spike protein is present as a fusion with the tissue plasminogen activator (tPA) sequence in the order N-terminus - tPA - spike protein - C-terminus. The invention also relates to uses and methods. |