http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018214327-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_87bafa95821ebef28ad11ad26a6b3942 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e2f6e296514636444f0de4cd66f7a24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-695 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-0015 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-695 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-58 |
| filingDate | 2017-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_301068133b784a52444e34b5972ee0cf |
| publicationDate | 2018-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2018214327-A1 |
| titleOfInvention | Preparation method for anti-cancer drug lanosterol derivative |
| abstract | The present invention pertains to the technical field of drug synthesis and relates to a preparation method for a novel anti-cancer drug lanosterol derivative. In the method, lanosterol is used as a starting material to produce an intermediate LD-a through protection by tert-Butyldimethylsilyl (TBS), the intermediate LD-a undergoes a Sharpless asymmetric double hydroxylation reaction under the action of osmium tetroxide (OsO 4 ) to produce a vicinal diol compound LD-b, the compound LD-b undergoes Swern oxidation under alkaline conditions of triethylamine to produce an α-hydroxyketone compound LD-c, LD-c is acylated with acetic anhydride to obtain an intermediate LD-d, LD-d undergoes TBS deprotection to obtain an intermediate LD-e, and finally the intermediate LD-e is epoxidized to give a target lanosterol derivative LD. The present invention has relatively mild reaction conditions in the preparation steps and short synthesis steps, avoids the use of highly toxic or expensive reagents, produces a product with high purity, and can be used for industrial production. |
| priorityDate | 2017-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 109.