| abstract |
Disclosed are an intermediate of Eribulin and a preparation method therefor. In particular, disclosed are compounds as represented by formula II, formula III and formula V and a preparation method therefor. Ar is C 1-10 alkyl substituted, alkyloxy substituted or unsubstituted aryl; R 1 and R 2 is an acetal protecting group or a thioacetal protecting group; R 3 is hydrogen or a hydroxyl protecting group; and X is halogen or a leaving group. The preparation method therefor has the advantages of mild reaction conditions, high selectivity, easy purification, low synthesis cost and the like, being suitable for large scale production. |