http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018209809-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_302ee02d4561a2298c3c88b4ecd64c47 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-08 |
| filingDate | 2017-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd9359ebb6626194799e1324ea28b64b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cee9a3e03866d1431c8d647385bf2b1c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c6d127ad2ea6207efece57cffca6441 |
| publicationDate | 2018-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2018209809-A1 |
| titleOfInvention | Polycrystalline mesylate of phosphodiesterase type 5 inhibitor, preparation method therefor, and application thereof |
| abstract | The present application relates to a polycrystalline mesylate of a phosphodiesterase type 5 inhibitor. The chemical name of the phosphodiesterase type 5 inhibitor is 5-[2-ethoxy-5-(4-methylpiperazin-1-yl-thiocarbonyl)phenyl]-1-methyl-3- n -propyl-1,6-dihydro-pyrazolo[4,3- d ]pyrimidin-7-thione. The polycrystalline mesylate of the phosphodiesterase type 5 inhibitor comprises diffraction peaks measured at the following 2θ reflection angles in an X-ray powder diffraction pattern: 7.1750° ± 0.2°, 7.6299° ± 0.2°, 8.8588° ± 0.2°, 13.2310° ± 0.2°, 14.3754° ± 0.2°, 14.8440 ± 0.2°, 15.2941° ± 0.2°, 17.1838° ± 0.2°, 20.0314° ± 0.2°, 20.8507° ± 0.2°, 21.2839° ± 0.2° , 21.7890° ± 0.2°, 22.2594° ± 0.2°, 23.0373 ± 0.2°, 25.1243° ± 0.2°, 25.4244° ± 0.2°, 26.1530° ± 0.2°, 28.1210° ± 0.2°, 30.0135° ± 0.2°, 31.4809° ± 0.2°, 32.3619° ± 0.2°, 37.2410° ± 0.2°, 37.6388° ± 0.2°, and 40.8286° ± 0.2°. The polycrystalline mesylate of the phosphodiesterase type 5 inhibitor not only improves drug activity, but also improves water solubility and bioavailability thereof, making up for the lack of research on crystalline drug forms of phosphodiesterase type 5 inhibitors. |
| priorityDate | 2017-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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