| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c731b1258bdc5ec03140bf17ca27dc40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8268e39ce70ff2ad19742e2a21d5a90c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-12 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0278
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate |
2018-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b55143ca9c037b8d3a61a5be300ba5d7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_295c113d726e5f807c379fb4204b1ace
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8597f8e5f6b32b15e4982ff8885ddac6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_027f717fe4e85e5e964bad5a539d994a |
| publicationDate |
2018-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2018209344-A1 |
| titleOfInvention |
Nsg mice lacking mhc class i and class ii |
| abstract |
A NOD.Cg- Prkdc n scid n H2rg n tm1 Wjl n /SzJ .(NOD- scid -IL2rϒ null , NSG) mouse which is genetically modified such that the NSG mouse lacks functional major histocompatibility complex I (MHC I) and lacks functional major histocompatibility complex II (MHC II) is provided according to aspects of the present, invention. According to specific aspects the genetically modified NSG mouse, is a NOD.Cg- Prkdc n scid n H2-K1 n tml Bpe n H2-Ab1 n eml Mvw n H2-D1 n tml Bpe n H2rg n tm Wjl n /SzJ (NSG -K n b n D n b n ) n null n ( IA n null n )) mouse, NSG - RIP-DTR ( K n b n D n b n ) n null n ( IA n null ) mouse, or a NOD.Cg- B 2 m n tml n n Une n PrKdc n scid n H2 n dlAb1-E n α n H2rg n tm1 Wjl /SzJ (NSG- B2M n null n (IA IE n null n )) mouse. Human, immune cells and/or human: tumor cells are administered to a genetically modified immunodeficient mouse according to aspects described herein and assays of one or more test substances can be performed using the provided mice. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2019110450-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11712026-B2 |
| priorityDate |
2017-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |