| abstract |
Compositions, systems, and methods for assessing or improving vascular health, treatments or treatment methods involving the same, systems and methods for diagnosing vascular health or impairment, and compositions and methods for use in treating endothelial glycocalyx to improving vascular health or treat a (vascular health-associated) disease or other condition, in human and non-human mammals are disclosed. Computer systems, hardware storage devices, and methods used to determine glycocalyx impairment using a dynamically extrapolated characterization of a plurality of microvascular vessels, diagnose a subject as suffering from glycocalyx dysfunction or impairment, and assess or determine the health, functionality, or impairment of the glycocalyx as a function of blood flow. Compositions comprising glucosamine, hyaluronan, fucoidan, and antioxidants improve vascular health by enhance synthesis of new glycocalyx, protecting existing glycocalyx against damage, and enhancing repair of damaged glycocalyx. |