| abstract |
The present invention relates to bilirubin derivative particles comprising a bilirubin derivative and a metal, their use, and their method of manufacture. Since the bilirubin derivative particles according to the invention form coordination bonds with various metals, the particles can be used in the diagnosis by MR, the diagnostic tomodensitometry, photoacoustic diagnosis, PET tomography diagnosis, or the optical diagnosis. Since the bilirubin derivative particles according to the invention bind to a platinum-based anti-cancer drug and are decomposed by light stimulation / active oxygen, the particles can release the anticancer drug encapsulated therein in those Outwardly, and because the particles exhibit anti-inflammatory and anticancer activity, the particles are materials related to the field of theranostics that can be used for diagnosis as well as treatment. In addition, since the bilirubin derivative particles according to the invention are reactive with active oxygen species, the particles may also be useful in the form of a composition, a sensor, a kit or an agent. contrast or apparatus for detecting the type and concentration of active oxygen species. |