| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d21cdd6c9aa2a56078633fd99c1537ae |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C317-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-48 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-48 |
| filingDate |
2018-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fef28ba365c7d07d96e042b63f93fc64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe64666db44e191aef120b9eab3ed435
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94cf8811b7dc661cd8b22ef730cdcdc2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1fedbf8c3e74748be95a203a01f3160d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3c2ef92912e29936eb92b9f8631bd2d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbee7db52dab01b0df33abe3b3d1c109 |
| publicationDate |
2018-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2018203192-A1 |
| titleOfInvention |
Novel process to prepare n-[2-[(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulphonyl) ethyl]-1, 3-dioxo-2,3-dihydro-1h-isoindol-4-yl]acetamide |
| abstract |
An alternative and improved process for the preparation of Apremilast (Formula I) and Apremilast form B or a pharmaceutically acceptable salt thereof is provided. The novel process includes hydrogenation in acetone, Cyclization and acetylation followed by condensation in methyl isobutyl ketone (MIBK) and acetic acid mixture in specific volume ratios. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021042153-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7083793-B2 |
| priorityDate |
2017-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |