| abstract |
Bioadhesive hydrogels comprising: gelatin, an alginate, a water-soluble crosslinking agent, such as carbodiimide (EDC), and fiber are encompassed herein. Exemplary bioadhesive hydrogels comprise cellulose fiber (CF). Also encompassed herein are methods of using bioadhesive hydrogels described herein for a variety of applications, including, without limitation, as medical sealants for soft and hard tissue repair, dental applications, and cosmetic applications. Use of bioadhesive hydrogels for at least one of closure of soft tissue sites wherein a tear has occurred, restoration of an intact structure to fractured teeth and/or bone, adherence of dental devices and appliances, and augmentation of cohesiveness of cosmetics to a body part are also encompassed herein. |