| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b1822f06b818d4f515e9330627b044bb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J9-005 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J31-006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0061
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-357
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-0005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-554
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-0052 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2018-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_574e91f365dac1158916d1dee1795ec9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f4703b573fbb83e7fddc69772433bc6 |
| publicationDate |
2018-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2018196581-A1 |
| titleOfInvention |
Dihydroartemisinin-steroid conjugate and preparation method and use thereof |
| abstract |
Disclosed is a dihydroartemisinin-steroid conjugate having the following general formula (I) or a pharmaceutically acceptable salt thereof, wherein the dihydroartemisinin molecule at the position 10 thereof is connected to the parent nucleus of the steroid through a linker X. Also disclosed in the present invention are a method for preparing the dihydroartemisinin-steroid conjugate and the use of the same in the preparation of a drug for treating cancers. The dihydroartemisinin-steroid conjugate of the present invention shows a very strong inhibitory activity on multiple tumour cell lines, has small toxicity, can penetrate the blood brain barrier and has very broad application prospects. |
| priorityDate |
2017-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |