http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018185110-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_85ff6e725385ab8f9cce00156335569d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-20043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-20022 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
| filingDate | 2018-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e231ebe49048a4b395a1de2f51bd8957 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_292ca3db84db1cdfcfc2a26fba07d290 |
| publicationDate | 2018-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2018185110-A1 |
| titleOfInvention | Novel expression vectors and uses thereof |
| abstract | The present invention relates to non-integrating viral expression vectors for use in repeated administration regimens for non-interg rating gene therapy, such as, but not limitted to in the treatment of cancer, which do not induce a long-term adaptive immune response in the patient. The present invention relates to the new vectors, as such, as well as to their medical uses. The non-integrating expression vectors comprise a DNA sequence encoding an E2 protein of Bovine Papilloma Virus type 1 (BPV1 ), comprising a DNA-binding dimerization domain, as well as an oligomerized DNA sequence, forming a binding site for an said E2 protein. Optionally, further at least 50% of all immunostimulatory sequences (ISSs) from the plasmid backbone, the promoter and/or the expression cassette of said vector can be removed and/or modified in such a way that the vectors do not activate an innate immune response in a mammalian cell. The present invention further relates to said non-integrating expres-sion vector for use in expressing a protein or fragment(s) thereof binding an antigen and/or cell signaling molecule associated with cancer, tumor(s) and/or solid tumor(s). |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3953484-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11155610-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11066465-B2 |
| priorityDate | 2017-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 273.