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filingDate 2018-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2018-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2018183435-A1
titleOfInvention Vlp-based bivalent ebola vaccines and methods of making and using same
abstract Disclosed herein are virus-like particle (VLP)-based bivalent vaccine compositions. The compositions may comprise a spherical retroviral Group- specific Antigen ("Gag") protein core and at least two Ebola glycoproteins. The at least two Ebola glycoproteins may be located at the exterior surface of the spherical Gag protein core, such that the VLP-based vaccine presents at least two Ebola glycoprotein antigens. In one aspect, the at least two Ebola glycoproteins are a Zaire (EBOV) glycoprotein, and a Sudan (SUDV) glycoprotein.
priorityDate 2017-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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