| abstract |
The invention relates to novel trimeric antigen binding molecules comprising three fusion polypeptides, each of the three fusion polypeptides comprising (a) a moiety capable of specific binding to a costimulatory TNF receptor family member, (b) a trimerization domain derived from human cartilage matrix protein (huCMP) of amino acid sequence of SEQ ID NO: l, and (c) a moiety capable of specific binding to a target cell antigen, and to methods of producing these molecules and to methods of using the same. |