| abstract |
The present invention relates to the use of compounds having an anti- heparanase activity of formu la [R - L 1 - Ar 1 - L - Ar] 2 - X, wherein X is selected from the group consisting of SO 2 , C 1 -C 4 a lkylene, linear or branched, and wherein Ζ 1 and Z 2 are the same or different and each of Ζ 1 and Z 2 is independently selected from the group consisting of O, S and CONH or it is absent, and Z 2 is in position 3 or 4 of the phenyl ring, each of Ar and Ar 1 is independently selected from the group consisting of or is absent, with the proviso that at least one of Ar and Ar 1 is present, each of L and L 1 is independently selected from the group consisting of N = N, NHCO, CONH, CO, S and O, or is absent, R is selected from the group consisting of COOH, ha logen, CH =CHCOOH, wherein W is selected from CH, O and N, or R is absent, for the treatment of diseases and disorders associated with a heparanase activity. |