| abstract |
A phthalazone hydroxamic acid compound, a preparation method therefor and an application thereof. A structural formula of the compound is represented by formula I: (I), wherein R1 and R2 are hydrogen atoms or halogen, Y is an oxygen atom, methylene, or difluorine-substituted methylene, Z is -NHCH2-, or (II) is a chemical bond, methylene, fluoro-methylene, or a double bond. The compound can be prepared by enabling carboxylic ester and carboxylic acid to react with hydroxylamine, or performing a deprotection reaction on protected hydroxamic acid, and has inhibitory activity on poly(ADP-ribose)polymerase and/or histone deacetylase. |