http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018169317-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6729b065750246c23b711a95c72ad775 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y113-12007 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0069 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-66 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02 |
| filingDate | 2018-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2885c95d45e2a340e7fa4ce7b780e30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a08d67db03553b1949965fdd0fe13c7d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f95eedc22e966d500562a3cba1853b5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b76d463d28db8f13c4027a3191f5767 |
| publicationDate | 2018-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2018169317-A1 |
| titleOfInvention | Mutant gaussia princeps luciferase having amplified bioluminescence intensity |
| abstract | The present invention relates to a Gaussia princeps luciferase mutant which is modified by site-specific mutagenesis to amplify the bioluminescence intensity of Gaussia princeps -derived luciferase. More particularly, the present invention relates to a single- or multiple-mutation Gaussia princeps luciferase prepared by substituting at least one of amino acids at positions 60, 88, 89, 90, and 103 of the amino acid sequence of Gaussia princeps Luciferase ( G Luc) with a different amino acid, a polynucleotide encoding the mutant sequence, a recombinant vector carrying the polynucleotide, a transformant anchoring the recombinant vector, a method for preparing a mutant Gaussia princeps luciferase improved in bioluminescence intensity from the transformant, and a kit comprising the mutant Gaussia princeps luciferase. The present invention can prepare a mutant Gaussia princeps luciferase improved in bioluminescence signal by mutating an amino acid residue playing a critical role in amplifying the bioluminescence signal of Gaussia princeps luciferase and can usefully apply the same to cell monitoring and drug screening. |
| priorityDate | 2017-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 122.