http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018160582-A8

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filingDate 2018-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f551bb993696a5d32ef0dab6fcead0c3
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publicationDate 2019-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2018160582-A8
titleOfInvention Adeno-associated virus (aav) clade f vector and uses therefor
abstract A recombinant adeno-associated virus (rAAV) vector comprising an AAVhu68 capsid produced in a production system comprising a nucleotide sequence of SEQ ID NO: 1, or a sequence at least 75% identical thereto which encodes SEQ ID NO:2. The AAVhu68 capsid comprises subpopulations of highly deamidated asparagine residues in asparagine - glycine pairs in the amino acid sequence of SEQ ID NO: 2. Also provided are compositions containing the rAAV and uses thereof. Additionally, rAAV having an engineered AAV capsid comprising at least one subpopulation of vpl or vp2 proteins having a Val at amino acid position 157 with reference to the AAVhu68 vpl numbering are provided.
priorityDate 2017-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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