http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018140984-A1

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filingDate 2018-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2018-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2018140984-A1
titleOfInvention Method for non-invasive monitoring of fluorescent tracer agent with background separation corrections
abstract A method of monitoring a time-varying fluorescence emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is disclosed that includes providing at least two measurements obtained from a patient before and after administration of the fluorescent agent that includes an Flr n meas n signal detected adjacent to the medium by a filtered light detector during illumination of the medium by excitatory-wavelength light, and at least one DR signal selected from: a DR n exmeas n DR n em n , and DR n em,filtered signal. The method further includes identifying a post-equilibration portion of the measurement data set and transforming each Flr n meas n signal within the post-equilibration portion of the measurement data set to an IF n agent signal representing a detected fluorescence intensity emitted solely by the fluorescent agent from within the medium. The disclosed method includes removing the effects of leak-through of excitation-level light and removing the effects of autofluorescence from the Flr n meas signal.
priorityDate 2017-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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