abstract |
A compound according to the general Formula (8): wherein R 1 is hydrogen or C 1 -C 4 alkyl; R 2 is C 1 -C 4 alkyl, benzyl, or 1 H -indol-3-ylmethyl; T is selected from the group consisting of -CH(OR3)-R4, -C(=O)-OR 3 , or -C(=O)-NR 3 R 5 , wherein R 3 is hydrogen or C 1 -C 4 alkyl; R 4 is phenyl; R 5 is hydrogen or C 1 -C 4 alkyl; L 1 is R 6 -C(=O)-R 7 ; where R 6 is C 1 -C 6 alkyl; R 7 is a bond or NH-NH; L 2 is a bond,, or; where n is 1-4; and Ab is an antibody or antigen-binding antibody fragment, and a process for preparing the same. In certain embodiments, Ab is an antibody or antigen-binding antibody fragment which binds to C4.4a. |