| abstract |
A substituted 1-(isoxazole-3-yl)-3-(3-fluorine-4-phenyl)urea derivative, and a preparation method therefor and a use thereof, relating to the technical field of organic synthesis of medicines. A substituted 1-(isoxazole-3-yl)-3-(3-fluorine-4-phenyl)urea derivative is provided, and the structural formula thereof is as represented by formula (I). Also provided is a preparation method for the substituted 1-( isoxazole-3-yl)-3-(3- fluorine-4-phenyl)urea derivative, and a use in preparing an FMS-fins-like tyrosine kinase 3 inhibitor. The present invention provides a novel effective choice for preparation of kinase inhibitors, preparation of medicines for treating autoimmune diseases, and preparation of angiogenesis inhibitors and antitumor medicines in the art, and has a very good application prospect. |